Proactive Anomaly Detection in Large-Scale Cloud-Native Databases

This disclosure describes techniques to identify anomalous patterns in customer workloads from database logs and to enable timely, corrective action that ensures uninterrupted operation of the database. Examples of anomalies include sudden increases (bursts) in the number of error messages written to a log file. An adaptive behavior norm is defined for each message type. Time instances or periods when the gap between messages of a given type in the database log deviate from the expected behavior norms are detected. A deviation from the behavior norm is a potential indicator of database problems. An anomaly detection tool outputs a ranked list of log statements exhibiting spikes of activity along with their time intervals that a database administrator (DBA) can examine to take corrective action. By automating anomaly detection, the valuable time of DBAs can be spent acting on issues rather than finding them

Asymptomatic SARS-CoV-2 infection among healthcare workers in a non-COVID-19 teaching university hospital

Background: During the COVID-19 pandemic, most of the published reports on COVID-19 emphasized that health care workers (HCWs) get infected more than the general population representing one of the most vulnerable groups. However, that the real percentage of HCWs infected by SARS-CoV-2 in Egypt remains unknown. The researchers conducted the current study to assess seroprevalence of SARS-CoV-2 IgG among HCWs working in a hospital with no SARS-CoV-2 patients, and to identify the potential factors associated with SARS-CoV-2 IgG seropositivity.Design and Methods: The current study is a cross-sectional study carried out among 455 HCWs at Cairo University Hospital. The researchers administered a questionnaire shortly before the SARS-CoV-2 rapid test is performed using closed-ended question format to obtain information on demographic data of the study participants including age, sex, specialty, clinical information including questions about medical conditions, and. history of previous exposure with a confirmed or suspected case of COVID-19, and history of COVID-19- compatible symptoms during the previous 14 days (cough, sore throat, runny nose, fatigue, shortness of breath, fever, headache, vomiting, diarrhea, anosmia, ageusia, and chills). Results: We screened 455 HCWs for SARS-CoV-2 antibodies, 31.4% were in the high-risk group, and 68.6% in the low-risk group. The overall IgG seroprevalence was 36 (7.9%) (95% CI 5.8 to 10.8). The IgG seroprevalence was significantly higher in low-risk group 11% (35/312) versus high-risk group 0.7% (1/143), p<0.001. Conclusions: Low seropositivity rates for SARS-CoV-2 among HCWs is suggestive of lack of immunity and we are still far from herd immunity

Expression Of Glucocorticoid Receptor Beta (GCR Β) In Asthmatic Patients And Its Correlation With Clinical Severity And Pulmonary Functions

N e w Y o r k S c i e n c e J o u r n a l 2 0 1 0 ; 3 Expression Of Glucocorticoid Receptor Beta (GCR Β) In Asthmatic Patients And Its Correlation With Clinical Severity And Pulmonary Functions Engy Yousry Elsayed , Enas M Foda, khaled AH Mohammed, Hassan Shalaby, Amal Z. Abd El-Halem* and Eman Ramzy** Internal Medicine, Clinical Pathology* and Chest** Departments Faculty Of Medicine, Ain Shams University, cairo, Egypt. [email protected] ABSTRACT Background: Glucocorticoids are the gold standard treatment of bronchial asthma. Although the majority of patients with asthma respond favorably to inhaled and systemic steroid therapy, a subset of asthmatics failed to demonstrate a satisfactory response even to systemic glucocorticoid therapy. GCR β (glucocorticoid receptor beta) is a hormone binding deficit isoform of GCR (glucocorticoid receptor) which has been isolated in humans and when over expressed, it may function as a dominant negative modulator of GCR. Aim of the work: This study was designed to determine the percentage of expression of GCRβ on PBMCs: (peripheral blood mononuclear cells )of asthmatic patients and to correlate it with the clinical severity and pulmonary functions. Subjects and Methods: 60 asthmatic patients (41 males, 19 females) and 20 healthy controls were enrolled in this study. Asthmatics were classified according to GINA guidelines (2002) into mild, moderate and severe asthma. They were subdivided into asthmatic on inhaled corticosteroid (ICS) (n=35) and those not on ICS (n=25). For all studied groups, spirometeric pulmonary functions and immunohisto-chemistry staining of PBMC S were performed to analyze percentage of expression of GCRβ on PBMCs. Results: It showed that the percentage of expression of GCRβ on PBMC S were statistically higher in all asthmatic patient groups compared to control, with higher % of expression in those not on ICS. Also a statistical significant higher % of expression of GCR β in severe asthmatics compared to both mild and moderate groups was detected. In conclusion: This study highlights the importance of glucocorticoid receptor beta isoform in pathogenesis of bronchial asthma and this may be directly linked to asthma severity and can affect the response to medications especially ICS

Perceptions and Experiences of Pursuing Research Among Medical Students in Problem-Based Learning Curriculum: A Cross-Sectional Study from Qatar

OBJECTIVES Early introduction to research prepares medical students for the practice of evidence-based medicine. Few studies have examined the experiences of research among medical students in the Arab region. This study assesses medical students’ experiences in pursuing research at the national College of Medicine (CMED) in the state of Qatar. METHODS This cross-sectional study was conducted using an online questionnaire distributed through Google Forms. The inclusion criteria called for students over 18 years old enrolled in the college in Years 2 to 6 (pre-clinical and clinical phases) during the spring semester of 2022. The questionnaire included 5 sections with multiple-choice questions and 5-point Likert-scale questions. The questionnaire was validated using esperts review and by piloting it on 10% of the eligible students. STATA 17.0 was used to perform the statistical analysis, which involved a logistic regression and Mann–Whitney U test. RESULTS The study had 179 student participants (over half of the eligible group). Half were in the preclinical phase, and half were in the clinical phase. Approximately half had published at least 1 paper. For voluntary research, the main motivators were passion and positive past experiences, while the main demoralizer was inadequate time. For mandatory medical-student research, supervisor help was the main facilitator, and an academic load leaving insufficient time for research was the main barrier. The factors positively influencing voluntary research participation were being older, being male, studying in a more advanced program phase, and having a lower score for negative attitudes toward research. The main limitation of the study was the inclusion of only 1 medical school with 1 type of curriculum. CONCLUSIONS Our findings suggest that better research experience can be ensured by providing space, time, and proper academic and moral support to students. The authors believe that doing so will indirectly positively affect the future translation of skills in evidence-based medicine into clinical practice

sj-pdf-2-mde-10.1177_23821205241227327 - Supplemental material for Perceptions and Experiences of Pursuing Research Among Medical Students in Problem-Based Learning Curriculum: A Cross-Sectional Study from Qatar

Supplemental material, sj-pdf-2-mde-10.1177_23821205241227327 for Perceptions and Experiences of Pursuing Research Among Medical Students in Problem-Based Learning Curriculum: A Cross-Sectional Study from Qatar by Reem R Al-Subai, Muhammad Z Kaleem, Doaa Hassanien, Meral Eldestawy, Mahmoud N Hamwi, Engy Elsayed, Amal S Al-Kawari, Habib H Farooqi and Suhad Daher-Nashif in Journal of Medical Education and Curricular Development</p

sj-docx-1-mde-10.1177_23821205241227327 - Supplemental material for Perceptions and Experiences of Pursuing Research Among Medical Students in Problem-Based Learning Curriculum: A Cross-Sectional Study from Qatar

Supplemental material, sj-docx-1-mde-10.1177_23821205241227327 for Perceptions and Experiences of Pursuing Research Among Medical Students in Problem-Based Learning Curriculum: A Cross-Sectional Study from Qatar by Reem R Al-Subai, Muhammad Z Kaleem, Doaa Hassanien, Meral Eldestawy, Mahmoud N Hamwi, Engy Elsayed, Amal S Al-Kawari, Habib H Farooqi and Suhad Daher-Nashif in Journal of Medical Education and Curricular Development</p

Evaluating physicians’ awareness and prescribing trends regarding proton pump inhibitors: a cross-sectional study

Introduction: Proton pump inhibitors (PPIs) are commonly used to treat acid-related disorders. Their appropriate use depends on the correct indications from the clinician. Owing to the high incidence of use and misuse, PPIs have been identified as an essential pharmacological class for developing deprescribing recommendations. Therefore, assessing physicians’ knowledge and practice regarding PPI usage is critical for paving the way toward targeted recommendations and efforts.Objective: This study aimed to assess Syrian physicians’ perceptions of proton pump inhibitors adverse effects, their benefit in upper gastrointestinal bleeding (UGIB) prophylaxis, and how these perceptions are related to PPI prescription practice.Methods: A cross-sectional study was performed using a web-based questionnaire distributed among Syrian physicians in internal medicine between 28 November and 23 December 2022. The questionnaire assessed perceptions and experiences of PPIs, concerns about specific adverse effects, and their effectiveness for UGIB prophylaxis, in addition to the different scenarios used to determine the best practice for appropriate treatment to manage minimal, mild, moderate, and high-risk UGIB patients.Results: A total of 473 participants completed the questionnaire, with median age ±SD was (28.46 ± 4.58), and most participants (83.3%) were residents. Approximately half of the participants (45.5%) agreed that discussion assistance was provided to continue or terminate PPIs properly. Only 8.9% were very familiar with published evidence of PPI adverse effects. Bone weakening and vitamin B12 deficiency were the most frequently reported side effects (81.8% and 79.7%, respectively). However, dementia (0.4%) and mortality (1.9%) were the least reported adverse effects. More than half of the participants (64%) perceived using PPIs to prevent upper GI bleeding. Non-trainee physicians were less knowledgeable about appropriate GERD management than resident physicians (p &lt; 0.001).Conclusion: The study showed a gap between Syrian physicians’ perceptions and practices regarding PPI use, which necessitates spreading awareness of updated guidelines for PPI usage and their side effects